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22nd August 2013 @ 10:11

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Reaction information

*#Reaction file  
*Reaction file type CDX
*Procedure  Perchloric acid (0.10 mL of a 70% solution in water, 1.2 mmol) was added dropwise to Ethyl(3,5-dimethoxyphenyl)acetate (224 mg, 1.0 mmol) in octanoic anhydride (1.80 mL, 6.0 mmol).  The reaction mixture was stirred at room temperature for 4 h, extracted with ether (35 mL), washed with sat. aq. NaHCO3solution (5 × 50 mL), dried (MgSO4), filtered and the solvent removed in vacuo to give the crude product as a green oil (630 mg). Purification by column chromatography (SiO2, hexane/Et2O 1:1) gave the title compound as an orange oil (116 mg, 33%).
*Yield (%)  33
*Type of Yield Isolated product yield
AH Thesis_2011_pp71.pdf
AH Thesis_2011_pp168-175.pdf
Further information  Compound 109a: 3,5-Dimethoxycytosoporone

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Overall reaction? True
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Attached Files
AH Thesis_2011_pp71.pdf
AH Thesis_2011_pp168-175.pdf