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22nd August 2013 @ 14:43

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Reaction information

*#Reaction file  
CSRxnsScheme_123j.cdx
*Reaction file type CDX
*Procedure  

General procedure C (see below) with ynamide 117j (4-Methyl-N-(4-(trimethylsilyl)but-3-yn-1-yl)-N-((trimethylsilyl)ethynyl)benzenesulfonamide) (374 mg, 1.0 mmol).  Purification by column chromatography (SiO2, hexane/Et2O 9:1) gave the title compound as a colourless oil (277 mg, 74%).

 

 

General procedure C:

n-BuLi (0.88 mL of a 2.5 M solution in hexanes, 2.2 mmol) was added dropwise to a solution of Cp2ZrCl2 (322 mg, 1.1 mmol) in dry THF (5.0 mL) at −78 °C.  A solution of the appropriate ynamide 117a-j or 131a,b (1.0 mmol) in dry THF (3.0 mL) was added dropwise at −78 °C.  The reaction mixture was warmed to room temperature and stirred for 5 h.  The reaction mixture was cooled to −78 °C and MeOH (10.0 mL) added.  After stirring at −78 °C for 1 h the reaction mixture was stirred at room temperature for 16 h.  The reaction mixture was poured into water (100 mL) and extracted with ether (3 × 50 mL).  The organic extracts were combined, washed sequentially with water (2 × 100 mL) and brine (100 mL), dried (MgSO4), filtered and the solvent removed in vacuo to give the crude product, which was purified as described.

*Yield (%)  74
*Type of Yield Isolated product yield
Reference(s)  
AH Thesis_2011_pp176-223.pdf
AH Thesis_2011_pp96.pdf
Further information  Compound 123j: (2Z,3E)-2,3-Dipentylidene-1-tosylpiperidine

For multistep reactions (or their steps):

Overall reaction? True
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For step in multistep reaction - link to previous reaction step  
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Attached Files
AH Thesis_2011_pp96.pdf
CSRxnsScheme_123j.cdx
AH Thesis_2011_pp176-223.pdf