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29th August 2013 @ 14:50

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Reaction information

*#Reaction file
Scheme_304.cdx
*Reaction file type CDX
*Procedure  

Into ice bath at 0°C, paraformaldehyde (30.0 g, 2.0 equivalents,) was added to a stirred mixture of methylamine (66 % solution in IMS, 15.0 g, 0.5 M), ethanol (250.0 mL) and potassium carbonate (69.0 g, 0.50 M).  The mixture was stirred vigorously for 3 days at room temperature, then filtered and distilled using a Dufton column (52 °C at 13mm Hg) to afford the title compound as a colourless oil (20.5 g, 140 mmol, 42 %).

*Yield (%)  42
*Type of Yield Isolated product yield
Reference(s)  
DM Thesis_2000_pp99.pdf
DM Thesis_2000_pp40-49.pdf
Further information  

For multistep reactions (or their steps):

Overall reaction? True
For overall reaction - links to child reaction steps  
For step in multistep reaction - link to previous reaction step  
For step in multistep reaction - link to following reaction step  
Attached Files
Scheme_304.cdx
DM Thesis_2000_pp99.pdf
DM Thesis_2000_pp40-49.pdf