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Characterization Template - Proton NMR
ChemSpider compound and associated data template
ChemSpider Reactions template
ChemSpider SyntheticPages style reaction template
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Reaction information
*#Reaction file | Scheme_405.cdx |
*Reaction file type | CDX |
*Procedure |
To a stirred solution of methyl propriolate (84.0 mg, 1.0 mmol) and boron trifluoride diethyl ether complex (0.40 mL, 3.0 mmol) dissolved in dichloromethane (1.0 mL) at –78 °C, 4-[(E)Butylidene]-3-[(Z)-1-(methylthio)methylidene]-1-(phenylmethyl)perhydroazepine (396, 0.304 g, 1.0 mmol) was added dropwise, warmed to room temperature and refluxed for 1 hrs. The product was extracted into diethyl ether (3 x 30 mL), the combined organic layer washed with water (3 x 30 mL), brine (30.0 mL), dried over MgSO4, filtered and solvent removed under reduced pressure. The title compound was isolated as a pale oil (162 mg, 0.48 mmol, 48 %).
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*Yield (%) | 48 |
*Type of Yield | Isolated product yield |
Reference(s) | DM Thesis_2000_pp148.pdf DM Thesis_2000_pp51-59.pdf |
Further information |
For multistep reactions (or their steps):
Overall reaction? | True |
For overall reaction - links to child reaction steps | |
For step in multistep reaction - link to previous reaction step | |
For step in multistep reaction - link to following reaction step |