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Characterization Template - Proton NMR
ChemSpider compound and associated data template
ChemSpider Reactions template
ChemSpider SyntheticPages style reaction template
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Reaction information
*#Reaction file | Scheme_440.cdx |
*Reaction file type | CDX |
*Procedure |
To a stirring solution of Ph3P+CH3Br- (7.86 g, 22.0 mmol) in THF (40.0 mL) at 0 °C, nBuLi (8.8 mL, 2.5 M solution in hexanes, 22.0 mmol) stirred for 15 minutes, 1-naphthalen-1-yl-ethanone (10.0 mmol, 1.70 g) was added then stirred for 15 hrs. The product was extracted into diethyl ether (3 x 50 mL), the combined organic layers washed with water (3 x 50 ml), brine (50.0 mL), dried over MgSO4, filtered and solvent removed under reduced pressure. The product was recrystallised from diethyl ether and pentane to afford the title product as a white crystalline solid (8.2 g, 8.2 mmol, 82 %). |
*Yield (%) | 82 |
*Type of Yield | Isolated product yield |
Reference(s) | DM Thesis_2000_pp70-75.pdf DM Thesis_2000_pp160.pdf |
Further information |
For multistep reactions (or their steps):
Overall reaction? | True |
For overall reaction - links to child reaction steps | |
For step in multistep reaction - link to previous reaction step | |
For step in multistep reaction - link to following reaction step |