URI
URI Label
Revisions
Add to List
Edit Entry
Export:
XML
Characterization Template - Proton NMR
ChemSpider compound and associated data template
ChemSpider Reactions template
ChemSpider SyntheticPages style reaction template
- August 2013 (212)
- July 2013 (495)
- June 2013 (331)
- May 2013 (2)
- April 2013 (9)
- 1 (6)
- A.Henderson (226)
- L. Sayer (48)
- Templates (5)
- D. Owen (249)
- D.Macfarlane (91)
- F. Giustiniano (148)
- ForChemSpider (70)
- ForCSSP (35)
- G. Saluste (54)
- Help (7)
- J. Stec (110)
Show/Hide Keys
This post is compatible for submission to ChemSpider Reactions.
See ChemSpider Reactions template - help and further information for help when using it.
Reaction information
| *#Reaction file | ReactionScheme.cdx |
| *Reaction file type | CDX |
| *Procedure |
Sodium borohydroxide (1.08 g, 29.00 mmol, 1 equiv.) in several portions was added to a solution of 3-bromobenzaldehyde (10 mL, 86.00 mmol, 3 equiv.) in ethanol (100 mL) at 25 °C. The mixture was stirred for 3 hours. The reaction was quenched with water (80 mL) and the product was extracted into ethyl acetate (2 x 100 mL). The ethyl acetate washes were combined and washed with brine (2 x 100 mL) before being dried over magnesium sulphate, filtered and concentrated under reduced pressure. The product was purified by bulb to bulb distillation (26 mmHg, 200 °C) to yield the product (9.68 g, 52 mmol, 60 %). |
| *Yield (%) | 60 |
| *Type of Yield | Isolated Product Yield |
| Reference(s) |
Callahan, J. F.; Lin, G.; Wan, Z.; Yan, H. WO2009/100166 A1, 2009 L.Sayerpp18-19.pdf
|
| Further information | Using the method of Callahan et al |
For multistep reactions (or their steps):
| Overall reaction? | False |
| For overall reaction - links to child reaction steps | N/A |
| For step in multistep reaction - link to previous reaction step | N/A |
| For step in multistep reaction - link to following reaction step | Reaction 51 |