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16th September 2013 @ 14:01

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Reaction information

*#Reaction file
ReactionScheme.cdx
 
*Reaction file type CDX 
*Procedure

To a stirred solution of 2-((3-(1-((3aR,6aR)-5-hexyl-4-phenyl-1,2,3,3a,6,6a-hexahydropentalen-3a-yl)vinyl)benzyl)oxy)acetic acid (assumed 82 mg from previous reaction) in DMF (0.6 mL) was added TSTU (54 mg, 0.18 mmol, 1 equiv.) and DIEA (0.07 mL, 0.36 mmol, 2 equiv.).  The reaction was stirred overnight. TLC showed the presence of a small amount of starting material so extra TSTU was added (0.001 g) however, after 2 hours the starting material still remained in the reaction mixture.  This crude material was used in the next step of the synthesis immediately. 

*Yield (%) -
*Type of Yield
Reference(s)
L.Sayerpp37.pdf
 
Further information

For multistep reactions (or their steps):

Overall reaction? False 
For overall reaction - links to child reaction steps N/A 
For step in multistep reaction - link to previous reaction step Reaction 70 
For step in multistep reaction - link to following reaction step N/A
Attached Files
ReactionScheme.cdx
L.Sayerpp37.pdf